| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na99mTcO4) and on the fixation of radioactivity on blood constituents
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| Autores: |
Diniz,Claudia Leite
Carmo,Fernanda Santos do
Almeida,Danielle Santos de
Santos-Filho,Sebastião David
Missailidis,Sotiris
Fonseca,Adenilson de Souza da
Bernardo Filho,Mario
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| Data: |
2008-12-01
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| Ano: |
2008
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| Palavras-chave: |
Biodistribution
Centella asiatica
Blood
Plasma
Technetium-99m
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| Resumo: |
This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract and, 1 hour after, Na99mTcO4 was administered; organs/tissues were withdrawn and weighted. The radioactivity was counted to calculate the percentage of activity per gram (%ATI/g). Also, blood samples were withdrawn, plasma (P), blood cells (BC), insoluble fraction (IF) and soluble fractions of P and BC were isolated and the radioactivity was counted to calculate the percentage of activity (%ATI). Data indicated that the acute treatment with CA extract changed significantly (p<0.05) the %ATI/g in several organs/tissues (spleen, heart, duodenum, stomach, liver, muscle, kidney, testis and blood) and the %ATI on the blood constituents (P, BC, IF-P and IF-BC). These results indicate that the substances or metabolites of the CA extract would change the biodistribution of Na99mTcO4 and the fixation of the technetium-99m on blood constituents in an acute treatment.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700035
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132008000700035
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.51 n.spe 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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